30 Ekim 2017 Pazartesi

Just published! A deductive article of Prenatal Thyroid Theory


A deductive article of Prenatal Thyroid Theory authored by Dr. Osman Sabuncuoglu has been just published in the journal, Mental Illness in October, 2017.

In the abstract, it says: "Research into the neurobiological origins of same-sex attraction is inconclusive. A recent theory of homosexuality posited that maternal thyroid dysfunction during pregnancy is associated with an increased rate of homosexual orientation in offspring. Relevant studies from the prenatal thyroid model perspective were reviewed, the major findings of which are as follows: i) An increased prevalence of Hashimoto’s disease in lesbian women suggests a maternal and even familial presence of the same autoimmune thyroid disease. Female-tomale transsexuals and lesbian women were also reported to have higher rates of polycystic ovary syndrome (PCOS). Over the last several years, reports suggesting a strong link between PCOS and thyroid autoimmunity have accumulated. ii) The increased risk of autism spectrum disorders (ASD) in the offspring of mothers with thyroid autoimmunity in pregnancy and the association between ASD and gender dysphoria indicate a link between maternal thyroid dysfunction and gender dysphoria/same-sex attraction in the offspring. iii) The high risk of miscarriage and retarded fetal growth in pregnancies of mothers who give birth to homosexual offspring can be explained by the impact of maternal thyroid dysfunction during pregnancy. This perspective review highlights relevant research findings and integrates them into the prenatal thyroid model of homosexuality. A better understanding of the mechanisms involved in the generation of same-sex orientation will contribute to the betterment of individual lives, as well as of society."

The article is accessible at: http://www.pagepress.org/journals/index.php/mi/article/view/7325

There are 2 Figures in the article, one of which clearly displays the mechanism of homosexuality in human beings.

7 Aralık 2016 Çarşamba

Hormones, Brain and Behavior (3rd Edition) has cited the thyroid-homosexuality proposal article

Probably the most authoritative book on the subject of interplay between what the title says, "Hormones, Brain and Behavior" has cited the thyroid-homosexuality proposal article in the latest edition published this month.

Edited by Pfaff DW & Joels M and published by the Academic Press, the key features of the book include;

  • Comprehensive and updated coverage of a rapidly growing field of research
  • Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics
  • Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research
  • Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior.

  • The citation refers to the 2015 study as: "...but the sample was relatively small and the percentage of homosexuality in the sample population was 2%, lower than in the general population (Sabuncuoglu, 2015)." However, that reasoning falls quite short, as a clinical sample of children and adolescents is unlikely to be similar to general population of mostly adult people. For instance, the ADHD percentage in a child psychiatry clinical population may be up to 40%, whereas it is expected to be about 5% in general child  population, and 2-3% in general adult population. While some neurodevelopmental disorders fade with age, some of them increase when minors grow up.



    26 Temmuz 2016 Salı

    An Editorial regarding the thyroid-homosexuality proposal article

    An Editorial entitled "A Link Between Maternal Thyroid Hormone and Sexual Orientation?" has been published in the journal Mental Illness regarding the thyroid-homosexuality proposal article.

    The author Jeffrey Mullen, from the University of California, Irvine, briefly summerizes the article and concludes: "...Whether or not maternal thyroid dysfunction causes homosexuality, this study presents data that strongly suggest that there is an association between the two. Though past research has not been able to attribute a single factor to the development of sexual orientation, future research may find additional contributing factors. Ultimately, this study has made a very compelling point concerning the very nature of gender nonconformity and sexual orientation. Those findings will likely prove to be important to our understanding of the topic, and will serve as a point of reference from which future research will be directed."

    Please refer to the following links for full text access:


    http://www.pagepress.org/journals/index.php/mi/article/view/6591

    http://www.ncbi.nlm.nih.gov/pubmed/27403279



    3 Aralık 2015 Perşembe

    The article of thyroid-homosexuality link has been indexed in PubMed

    PubMed is the most widely used search portal for biomedical research.

    In addition, the free, full-text article of prenatal thyroid model is also available at PubMed Central (PMC), which is the U.S. National Institutes of Health (NIH) digital archive of biomedical and life sciences journal literature.

    http://www.ncbi.nlm.nih.gov/pubmed/26605033

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620281/


    1 Mayıs 2015 Cuma

    EPA Talk of Dr. Osman Sabuncuoglu


    *Dear Collagues,
    I am going to present you my study which aimed to explore the relationship between maternal thyroid dysfunction in pregnancy and same-sex attraction/gender nonconformity in the offspring.
    *Although same-sex attraction is not a psychiatric disorder, both youngsters and adults with same-sex attraction are at greater risk for negative health outcomes.
    *It is accepted that early biological events generated by genes and prenatal sex hormones determine an individual’s sexual orientation.
    *However, despite mounting efforts, a satisfactory conclusion has not been reached and there is a need to explore alternate factors like functioning of thyroid system during pregnancy.
    *We believe that, besides fostering greater tolerance of homosexuality on behalf of society, clinicians are required to prevent negative health outcomes associated with it which may be better addressed by understanding the roots of homosexual behavior.
     *This retrospective chart review was undertaken of 790 eligible children and adolescents who had been admitted to child psychiatry between 2005 and 2013.
    *This population consisted of 520 (65%) males and 270 (35%) females, aged 8 to17 years.
    *Certain children were not included. 
    *What we found was fifteen mothers (1.8%) having a history of thyroid dysfunction during pregnancy and Sixteen youngsters (2%) having a history of same-sex attraction/gender nonconformity.
    *Twelve overlapping cases were identified, which was extremely significant.  Clinical features can be seen in Table 1. Comparisons can be seen in Figure 1.
    *The association was also significant for each sex.
    *As conclusion, it is possible to say that, thyroid gland and its hormones play a crucial role in determining sexual orientation in people.
    *Maternal thyroid dysfunctions during pregnancy may result in homosexual orientation in the offspring.
    *We have collateral evidences in 2 studies only, before.
    *This study is the only one that explored this association with a focused objective and found positive results. Thus, I propose the prenatal thyroid model to explain the causality of homosexuality.
    *For a variety of reasons, this link remained undetected; please refer to the poster or article for a full discussion of this matter.
    * Either present before pregnancy or developed afterwards, thyroid diseases may result in diminished supply of thyroid hormones which are crucial for optimal brain development. Developing brain areas, which will be responsible for determining heterosexual orientation remain undifferentiated without the influence of essential thyroid hormones.
    *More clinical and research attention is required.
    * There is a real need to review all relevant cultural, legal, political and even historical aspects of the topic from the medical standpoint explained in this study. It is only with the rule of science and knowledge that certain misconceptions and misperceptions will be cleared up and humankind will benefit.